Category: Featured Publications
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Temporal basis function models for closed-loop neural stimulation
Authors: Bryan, M.J., Schwock, F., Yazdan-Shahmorad, A. and Rao, R.P.N. Publication: J. Neural Engineering Date: September 16, 2025 Abstract: Objective. Closed-loop neural stimulation provides novel therapies for neurological diseases such as Parkinson’s disease (PD), but it is not yet clear whether artificial intelligence (AI) techniques can tailor closed-loop stimulation to individual patients or identify new…
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Early intervention with electrical stimulation reduces neural damage after stroke in non-human primates
Authors: Zhou, J., Khateeb, K. and Yazdan-Shahmorad, A. Publication: Nature Communications Date: July 21, 2025 Abstract: For patients experiencing ischemic stroke, acute intervention offers the most critical therapeutic opportunity as it can reduce irreversible tissue injury and improve functional outcomes. However, currently available treatments within the acute window are highly limited and have strict patient…
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Manipulation of neuronal activity by an artificial spiking neural network implemented on a closed-loop brain-computer interface in non-human primates
Authors: Mishler, J.H., Yun, R., Perlmutter, S., Rao, R.P.N. and Fetz, E.E. Publication: J. Neural Eng. Date: July 21, 2025 Abstract: Objective. Closed-loop brain-computer interfaces can be used to bridge, modulate, or repair damaged connections within the brain to restore functional deficits. Towards this goal, we demonstrate that small artificial spiking neural networks can be…
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The “Wheels That Keep Me Goin’”: Invisible Forms of Support for Brain Pioneers
Authors: Brown, A.I., MacDuffie, K.E., Goering,S., Klein, E. Publication: Neuroethics Date: March 26, 2025 Abstract: Research participants in long-term, first-in-human trials of implantable neural devices (i.e., brain pioneers) are critical to the success of the emerging field of neurotechnology. How these participants fare in studies can make or break a research program. Yet, their ability…
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Flexible modeling of large-scale neural network stimulation: Electrical and optical extensions to The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX)
Authors: Pierce, A.F., Shupe, L., Bloch, J., Fetz, E. and Yazdan-Shahmorad, A. Publication: Journal of Neuroscience Methods Date: June 13, 2025 Abstract: Computational models that predict effects of neural stimulation can serve as a preliminary tool to inform in-vivo research, reducing costs, time, and ethical considerations. However, current models do not support the diverse neural…
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Neural populations are dynamic but constrained
Authors: Orsborn, A.L. Publication: Nature Neuroscience Date: January 17, 2025 Abstract: Our brains evolved to help us rapidly learn new things. But anyone who has put in hours of practice to perfect their tennis serve, only to reach a plateau, can attest that our brains aren’t infinitely flexible. New work shows that patterns of neural…
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Natural behaviour is learned through dopamine-mediated reinforcement
Authors: Kasdin, J.*, Duffy, A.*, Nadler, N., Raha, A., Fairhall, A.L., Stachenfeld, K. and Gadagkar, V. Publication: Nature Date: March 12, 2025 Abstract: Many natural motor skills, such as speaking or locomotion, are acquired through a process of trial-and-error learning over the course of development. It has long been hypothesized, motivated by observations in artificial…
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Type-2 Diabetes alters hippocampal neural oscillations and disrupts synchrony between the hippocampus and cortex
Authors: Rabiller, G., Ip, Z., Zarrabian, S., Zhang, H., Sato, Y., Yazdan-Shahmorad, A. and Liu, J. Publication: Aging and Disease Date: October 1, 2024 Abstract: Type 2 diabetes mellitus (T2DM) increases the risk of neurological diseases, yet how brain oscillations change as age and T2DM interact is not well characterized. To delineate the age and…
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Multifunctional neural probes enable bidirectional electrical, optical, and chemical recording and stimulation in vivo
Authors: Driscoll, N., Antonini, M.J., Cannon, T.M., Maretich, P., Olaitan, G., Van, V.D.P., Nagao, K., Sahasrabudhe, A., Paniagua, E.V., Frey, E.J., Kim, Y.J., Hunt, S., Hummel, M., Mupparaju, S., Jasanoff, A., Venton, B.J. and Anikeeva, P. Publication: Advanced Materials Date: November 6, 2024 Abstract: Recording and modulation of neuronal activity enables the study of brain…
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From an ethics ‘side dish’ to ‘your modus operandi’: neurotechnology researcher perspectives on the impacts of a decade of embedded ethics collaboration
Authors: Tubig, P. A., Brown, T. E., McCusker, D., Pham, M., Klein, E., & Goering, S. Publication: J. Resp. Innovation Date: October 24, 2024 Abstract: In this paper, we discuss ethics integration and consider questions about evaluating the success of such efforts by reporting qualitative data from an interview study with researchers who were part…
