Category: Featured Publications

Authors: Guest, J. and Moritz, C.  Publication: Spinal Cord Date: March, 2026 Abstract: The unique challenges of tSCS clinical trials necessitate innovative methodological approaches beyond traditional placebo-controlled designs. Sequential self-controlled designs, biomarker-guided studies, and adaptive trial methodologies offer scientifically sound alternatives that respect participant welfare while generating robust evidence. Future research should pursue dual paths:…

Authors: Hong, N., Montalvo Vargo, S., Hatanaka, G., Gong, Z., Stanis, N., Zhou, J., Belloir, T., Wang, R.K., Bair, W., Chamanzar, M. and Yazdan-Shahmorad, A. Publication: Adv Sci (Weinh) Date: January, 2026 Abstract: Multimodal neural interfaces that integrate electrical and optical functionalities are promising tools for neuroscientific and clinical applications that involve recording and manipulating…

Authors: Rembado, I., Ravan, M., Akerman, M., Sanchez, M.M., Bascoc, K.J., Birch, C., Boyd, H., Amoeni, B., Morse, A., Kemp, I., Hur, J.W., Perlmutter, S., Su, D., Sison, C., Fetz, E.E. and Zanos S. Publication: Brain Stimulation Date: March, 2026 Abstract: Stimulation of sensory vagal pathways is typically delivered via invasive, cervical vagus nerve stimulation…

Authors: Lydia I. Smith and Amy L. Orsborn Publication: Journal of Neuroscience Methods Date: December, 2025 Abstract: BackgroundNeuroscience researchers often surgically implant hardware into model organisms to measure and manipulate neural activity. Designing and optimizing these procedures in non-human primates often requires sedated or euthanized animals. Artificial tissue technologies can reduce animal use in this process, but existing simulators…

Authors: Bryan, M.J., Schwock, F., Yazdan-Shahmorad, A. and Rao, R.P.N. Publication: J. Neural Engineering Date: September 16, 2025 Abstract: Objective. Closed-loop neural stimulation provides novel therapies for neurological diseases such as Parkinson’s disease (PD), but it is not yet clear whether artificial intelligence (AI) techniques can tailor closed-loop stimulation to individual patients or identify new…

Authors: Zhou, J., Khateeb, K. and Yazdan-Shahmorad, A. Publication: Nature Communications Date: July 21, 2025 Abstract: For patients experiencing ischemic stroke, acute intervention offers the most critical therapeutic opportunity as it can reduce irreversible tissue injury and improve functional outcomes. However, currently available treatments within the acute window are highly limited and have strict patient…

Authors: Mishler, J.H., Yun, R., Perlmutter, S., Rao, R.P.N. and Fetz, E.E. Publication: J. Neural Eng. Date: July 21, 2025 Abstract: Objective. Closed-loop brain-computer interfaces can be used to bridge, modulate, or repair damaged connections within the brain to restore functional deficits. Towards this goal, we demonstrate that small artificial spiking neural networks can be…

Authors: Brown, A.I., MacDuffie, K.E., Goering,S., Klein, E. Publication: Neuroethics Date: March 26, 2025 Abstract: Research participants in long-term, first-in-human trials of implantable neural devices (i.e., brain pioneers) are critical to the success of the emerging field of neurotechnology. How these participants fare in studies can make or break a research program. Yet, their ability…

Authors: Pierce, A.F., Shupe, L., Bloch, J., Fetz, E. and Yazdan-Shahmorad, A. Publication: Journal of Neuroscience Methods Date: June 13, 2025 Abstract: Computational models that predict effects of neural stimulation can serve as a preliminary tool to inform in-vivo research, reducing costs, time, and ethical considerations. However, current models do not support the diverse neural…

Authors: Orsborn, A.L. Publication: Nature Neuroscience Date: January 17, 2025 Abstract: Our brains evolved to help us rapidly learn new things. But anyone who has put in hours of practice to perfect their tennis serve, only to reach a plateau, can attest that our brains aren’t infinitely flexible. New work shows that patterns of neural…